Dry and wet lab experiences of certain curcumin analogues’ antibacterial effect on S.aureus

Curcumin analogues are widely used in numerous biological disciplines. They employed the pharmaceutical sector and offer good pharmacology application prospects present era. In current study, two curcumin analogues—1,7-diphenylhepta-1,6-diene-3,5-dione (DPHDD) 1,7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione (BDMPHDD)—were tested vitro against bacterial strain S. aureus. The testing demonstrated that ligands may have antibacterial potential. rule of five was to pre-filter compounds' drug-like characteristics prior computer analysis. Then, determine mechanism by which compounds limit growth aureus, molecular docking research carried out using AutoDock 4.2 tool. Six distinct target proteins from aureus were chosen for this purpose (PDB ID: 1T2P, 3U2D, 2W9S, 1N67, 2ZCO, 4H8E). protein Dihydrofolate reductase enzyme 2W9S) Staphylococcus sortase-A 1T2P) a binding affinity analogues, (BDMPHDD) & respectively.Due inactivation these enzymes, substances 1,7-diphenylhepta-1,6-diene-3,5-dione exhibit significant growth-inhibitory potential